Author:
Burla Maria Cristina,Carrozzini Benedetta,Cascarano Giovanni Luca,Giacovazzo Carmelo,Polidori Giampiero
Abstract
A new probabilistic formula estimating triplet invariants and capable of exploiting a model electron-density map gradually created during theab initiophasing process has been tested on a set of protein structures with data at non-atomic resolution. All the structures contain heavy atoms larger than Ca, and show a structural complexity which may attain the level of about 8000 non-hydrogen atoms in the asymmetric unit. It is shown that the majority of such structures may be solved by our direct methods procedure, which, in combination with a number of ancillary phasing tools, weakens the traditional expectation that atomic resolution is a necessary ingredient for the success of a directab initiophasing.
Publisher
International Union of Crystallography (IUCr)
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
9 articles.
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