(3β,5α,25R)-12-(Hydroxyimino)spirostan-3-yl acetate

Abstract

The title steroid, C29H45NO5, obtained by condensation of hecogenin acetate [systematic name: (3β,5α,25R)-12-oxospirostan-3-yl acetate] with NH2OH, has the oxime group substituting the C-12 site on theCring of the steroid nucleus. The introduction of this functional group allows the formation of chain motifs, using the oxime OH group as a donor and the O atom of theEring as an acceptor. TheC(8) chains formed by this intermolecular hydrogen bond are oriented parallel to the short cell axisa. The structural features of this compound are very close to those of C29H43NO5, the derivative with a C14=C15 double bond in theDring, which crystallizes in the same space group and with similar unit-cell parameters.