Author:
Zhang Qun-Zheng,Zhong Zhen-Hua,Hao Ding,Feng Ming-Nan,Wang Si-Chang,Han Qi-Long,Bai Yajun,Xu Danni,Liao Sha,Xiao Chaoni,Zhang Xun-Li,Zheng Xiaohui
Abstract
α-Asaronol [or (E)-3′-hydroxyasarone; systematic name: (E)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-ol; C12H16O4] was synthesized towards the development of a potential antiepileptic drug. Following purification by recrystallization, single crystals of α-asaronol were obtained by a liquid interface diffusion method at room temperature. The product was characterized by 1H and 13C NMR, and FT–IR spectroscopic analysis. X-ray crystallography revealed the title crystal to belong to the orthorhombic space group P212121. Preliminary bioassays with mouse neuroblastoma N2a cells demonstrated the neuroprotective activities of the synthesized α-asaronol.
Funder
National Natural Science Foundation of China
Key Research and Development Program of Shaanxi Province
Scientific Research Program of Shaanxi Provincial Education Department
Natural Science Basic Research Plan of Shaanxi Province
National College Students Innovation and Entrepreneurship Training Program
Graduate Innovation and Practice Skills Foundation of Xi'an Shiyou University
the Primary R&D Plan of Shaanxi Province
the Innovation and Entrepreneurship Training Program of Northwest University
Publisher
International Union of Crystallography (IUCr)
Subject
Materials Chemistry,Inorganic Chemistry,Physical and Theoretical Chemistry,Condensed Matter Physics
Cited by
2 articles.
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