Author:
Lam Su Datt,Das Sayoni,Sillitoe Ian,Orengo Christine
Abstract
Computational modelling of proteins has been a major catalyst in structural biology. Bioinformatics groups have exploited the repositories of known structures to predict high-quality structural models with high efficiency at low cost. This article provides an overview of comparative modelling, reviews recent developments and describes resources dedicated to large-scale comparative modelling of genome sequences. The value of subclustering protein domain superfamilies to guide the template-selection process is investigated. Some recent cases in which structural modelling has aided experimental work to determine very large macromolecular complexes are also cited.
Funder
Ministry of Higher Education, Malaysia
Biotechnology and Biological Sciences Research Council
Publisher
International Union of Crystallography (IUCr)
Cited by
46 articles.
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