Structure ofMycobacterium tuberculosisphosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation
Author:
Publisher
International Union of Crystallography (IUCr)
Subject
Condensed Matter Physics,Genetics,Biochemistry,Structural Biology,Biophysics
Link
http://journals.iucr.org/f/issues/2011/05/00/gx5183/gx5183.pdf
Reference25 articles.
1. Allosteric Properties of Inosine Monophosphate Dehydrogenase Revealed through the Thermodynamics of Binding of Inosine 5‘-Monophosphate and Mycophenolic Acid. Temperature Dependent Heat Capacity of Binding as a Signature of Ligand-Coupled Conformational Equilibria
2. MolProbity: all-atom structure validation for macromolecular crystallography
3. Structures of phosphopantetheine adenylyltransferase fromBurkholderia pseudomallei
4. Crystallization and preliminary crystallographic analysis of merohedrally twinned crystals of MJ0729, a CBS-domain protein fromMethanococcus jannaschii
5. Purification and Characterization of Phosphopantetheine Adenylyltransferase from Escherichia coli
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1. Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design;Frontiers in Molecular Biosciences;2022-05-30
2. Design of Novel Phosphopantetheine Adenylyltransferase Inhibitors: A Potential New Approach to Tackle Mycobacterium tuberculosis;Current Topics in Medicinal Chemistry;2021-09-23
3. A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis;Proteomics and Systems Biology;2021
4. Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents;Frontiers in Cellular and Infection Microbiology;2020-12-15
5. Crystal Packing of Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis in Two Crystal Modifications;Crystallography Reports;2020-01
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