Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations-Reference-Cited by-同舟云学术

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

Published:2011-12-09 Issue:1 Volume:68 Page:13-25
ISSN:0907-4449
Container-title:Acta Crystallographica Section D Biological Crystallography
language:
Short-container-title:Acta Crystallogr D Biol Cryst

Author:

Xu Yechun,Li Min-jun,Greenblatt Harry,Chen Wuyan,Paz Aviv,Dym Orly,Peleg Yoav,Chen Tiantian,Shen Xu,He Jianhua,Jiang Hualiang,Silman Israel,Sussman Joel L.

Publisher

International Union of Crystallography (IUCr)

Subject

General Medicine,Structural Biology

Link

http://journals.iucr.org/d/issues/2012/01/00/wd5167/wd5167.pdf

Reference105 articles.

1. PHENIX: building new software for automated crystallographic structure determination

2. Analysis of crystal structures of aspartic proteinases: On the role of amino acid residues adjacent to the catalytic site of pepsin-like enzymes

3. Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues

4. Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1

5. Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase‡

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