SIR2000-N, a program for large and small crystal structures

Abstract

The programSIR2000[Burlaet al.(2000).Acta Cryst.A56, 451–457] was designed for theab initiosolution of macromolecular crystal structures, provided that the data resolution is no lower than 1.2 Å. As the phasing procedure ofSIR2000is rather time consuming, modifications have been introduced to improve its efficiency and to make it additionally suitable for small molecules (new versionSIR2000-N). The role of the tangent refinement in modern phasing procedures is enlightened.