Using image analysis for automated crystal positioning in a synchrotron X-ray beam for high-throughput macromolecular crystallography-Reference-Cited by-同舟云学术

Using image analysis for automated crystal positioning in a synchrotron X-ray beam for high-throughput macromolecular crystallography

Published:2004-03-17 Issue:2 Volume:37 Page:265-269
ISSN:0021-8898
Container-title:Journal of Applied Crystallography
language:
Short-container-title:J Appl Cryst

Author:

Andrey Philippe,Lavault Bernard,Cipriani Florent,Maurin Yves

Abstract

A fully automated method for detecting and centring protein crystals for X-ray crystallography is described. It relies on the analysis of rotating crystal trace images. No assumption is made concerning the shape, absolute size, or position of the crystal within its holder. Crystals as small as 15 µm were successfully positioned. This represents an important step towards high-throughput structural studies.

Publisher

International Union of Crystallography (IUCr)

Subject

General Biochemistry, Genetics and Molecular Biology

Link

http://journals.iucr.org/j/issues/2004/02/00/ea5011/ea5011.pdf

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