Crystal structure of bis[1-(2-hydroxyethyl)-2-methyl-5-nitro-1H-imidazole-κN3]silver(I) tetrafluoridoborate methanol monosolvate

Abstract

1-(2-Hydroxyethyl)-2-methyl-5-nitro-1H-imidazole (metronidazole, MET) is a medication that is used to treat infections by a variety of anaerobic organisms, but there are relatively few reports of the structures of metal compounds that exhibit coordination of metronidazole. We have demonstrated that MET reacts with AgBF4to give [Ag(MET)2]BF4·CH3OH, in which the AgIcation is coordinated by two MET ligands with atransarrangement. The structure of [Ag(MET)2]BF4exhibits some interesting differences from its nitrate counterpart, [Ag(MET)2]NO3[Funet al.(2008).Acta Cryst.E64, m668]. For instance, although the two MET ligands of both [Ag(MET)2]BF4and [Ag(MET)2]NO3are almost coplanar, the former compound has ananti-like geometry with a molecular inversion center, but the latter has asyn-like arrangement. In the crystal, the BF4−anion is linked by an O—H...F hydrogen bond to the methanol solvent molecule, which is, in turn, linked to the cation by an O—H...O hydrogen bond; the components of the structure are linked by O—H...O hydrogen bonds, forming chains along [001]. One of the MET ligands and the BF4−anion are disordered over two sets of sites with ratios of refined occupancies 0.501 (17):0.499 (17) and 0.539 (19):0.461 (19), respectively.