Author:
Suchojad Kamil,Dołęga Anna,Adamus-Grabicka Angelika,Budzisz Elżbieta,Małecka Magdalena
Abstract
The synthesis and crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one, C16H12O3, I, and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one, C22H16O3, II, are reported. These compounds are of interest with respect to biological activity. Both structures display intermolecular C—H...O and O—H...O hydrogen bonding, forming layers in the crystal lattice. The crystal structure of compound I is consolidated by π–π interactions. The lipophilicity (logP) was determined as it is one of the parameters qualifying compounds as potential drugs. The logP value for compound I is associated with a larger contribution of C...H interaction in the Hirshfeld surface.
Funder
Uniwesytet Łódzki, Uniwersytet Medyczny w Łodzi
Publisher
International Union of Crystallography (IUCr)
Subject
Condensed Matter Physics,General Materials Science,General Chemistry
Reference50 articles.
1. Interaction of Arylidenechromanone/Flavanone Derivatives with Biological Macromolecules Studied as Human Serum Albumin Binding, Cytotoxic Effect, Biocompatibility Towards Red Blood Cells
2. 3-Benzylidene-6-methoxychroman-4-one
3. Biruntha, K., Reuben Jonathan, D., Mohamooda Sumaya, U., Dravida Thendral, E. R. A. & Usha, G. (2018). IUCrData, 3, x181273.
4. 2,3-Dihydro-7-hydroxy-3-[(4-methoxyphenyl)methylene]-4H-1-benzopyran-4-one
5. Design, Synthesis and Cytotoxicity of Novel Chalcone Analogs Derived from 1-Cyclohexylpyrrolidin-2-one and 2,3-Dihydrobenzo[f]chromen-1-one
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