Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K

Abstract

The low (90 K) and room (298 K) temperature crystal structures of topiramate azidosulfate [systematic name 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose azidosulfate], C12H19N3O8S, an intermediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azidosulfate (I) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.