Structure of the MarR family protein Rv0880 fromMycobacterium tuberculosis

Abstract

Rv0880 from the pathogenMycobacterium tuberculosisis classified as a MarR family protein in the Pfam database. It consists of 143 amino acids and has an isoelectric point of 10.9. Crystals of Rv0880 belonged to space groupP1, with unit-cell parametersa= 54.97,b= 69.60,c= 70.32 Å, α = 103.71, β = 111.06, γ = 105.83°. The structure of the MarR family transcription regulator Rv0880 was solved at a resolution of 2.0 Å with anRcrystandRfreeof 21.2 and 24.9%, respectively. The dimeric structure resembles that of other MarR proteins, with each subunit comprising a winged helix–turn–helix domain connected to an α-helical dimerization domain.