HARNESSING GOLD NANORODS FOR NON-ENZYMATIC GLUCOSE SENSING

Abstract

This study presents a straightforward and non-enzymatic approach for glucose detection utilizing aggregated gold nanorods (GNRs) based on surface plasmon resonance (SPR). The GNRs exhibited enhanced sensitivity toward glucose concentrations of up to 10 mM. The LSPR-based glucose detection method demonstrated superior sensitivity, stability, ease of use, and a convenient readout. Moreover, the LSPR detection technique can be seamlessly integrated with various sensing platforms, offering the potential to expand the sensor's range and applicability. This study highlights the promising prospects of LSPR-based non-enzymatic glucose detection and its potential for integration into diverse sensing systems. For the 10 mM glucose solution, the addition of 5.85x109 GNRs caused a 136 nm shift. On the other hand, when 50 mM glucose is added, the shift amounted to 82 nm, while adding 100 mM glucose resulted in a shift of 71 nm. This implies that at lower glucose concentrations, the degree of aggregation is greater, suggesting a heightened sensitivity to smaller concentrations. TEM images depicted the formation of the gold nanorod aggregates upon the introduction of 10 mM glucose.