Author:
Buduru Gowthami ,S.V. Gopala Krishna ,D. Subba Rao
Abstract
Oral administration is considered as major, convenient route among all other routes of delivery, owing to several benefits. But, the poor solubility or enzymatic/metabolic activity are the major concerns in developing a successful formulation. About 40% of approved drugs which are in the current market and 90% of new drug molecules in the developmental pipeline are hydrophobic in nature. The challenge to formulate insoluble drugs has met with various approaches to overcome the problems related to solubility, application of nanotechnology is one amongst them. The present review deals with various nanocarriers and technologies that are proven to be effective in enhancing the bioavilability of poorly soluble drugs.
Reference44 articles.
1. Naveen, N.R., Gopinath, C., Rao, D.S. (2017) Design expert supported mathematical optimization of repaglinide gastroretentive floating tablets: In vitro and in vivo evaluation. Future J. Pharm. Sci. 3(2):140-147. https://doi.org/10.1016/j.fjps.2017.05.003
2. U Agrawal, R Sharma, M Gupta, S.P.Vyas,. (2014) Is nanotechnology a boon for oral drug delivery? Drug Discovery Today, 19(10) 1530–1546.
3. Naveen, N. R., Gopinath, C., & Kurakula, M. (2020). Okra-thioglycolic acid conjugate-synthesis, charac-terization, and evaluation as a mucoadhesive pol-ymer. Processes, 8(3), 316. https://doi.org/10.3390/pr8030316
4. T. Hetal, P. Bindesh, and T. Sneha, (2010) A review on techniquesfor oral bioavailability enhancement of drugs, InternationalJournal of Pharmaceutical Sciences Review and Research,4 (3) 203–223.
5. T Mallamma, DR Bharathi, RG Lakshmi, T Vyjayanthimala, J Nagasubbareddy, R Naveen (2014), Etoposide-loaded nanoparticles made from poly-e-caprolactone (PCL): formulation, character-ization, in vitro drug release for controlled drug de-livery system, Int. J. Biopharm 5, 5-12