Abstract
Background: Obesity classifications vary globally and the impact of older age adiposity on incident diabetes has not been well-studied.Methods: We examined a random sample of 2,809 participants aged ≥60 years in China, who were free of diabetes at baseline and were followed up for up to 10 years to document diabetes (<i>n</i>=178). The incidence of diabetes was assessed in relation to different cut-off points of body mass index (BMI) and waist circumference (WC) in multiple adjusted Cox regression models.Results: The diabetic risk in the cohort increased linearly with the continuous and quartile variables of BMI and WC. The BMI-World Health Organization (WHO) and BMI-China criteria analysis did not show such a linear relationship, however, the BMI-Asian/Hong Kong criteria did; adjusted hazards ratio (HR) was 0.42 (95% confidence interval [CI], 0.20 to 0.90) in BMI <20 kg/m<sup>2</sup>, 1.46 (95% CI, 0.99 to 2.14) in 23–≤26 kg/m<sup>2</sup>, and 1.63 (95% CI, 1.09 to 2.45) in ≥26 kg/m<sup>2</sup>. The WC-China criteria revealed a slightly better prediction of diabetes (adjusted HRs were 1.79 [95% CI, 1.21 to 2.66] and 1.87 [95% CI, 1.22 to 2.88] in central obese action levels 1 and 2) than the WC-WHO. The combination of the BMI-Asian/Hong Kong with WC-China demonstrated the strongest prediction. There were no gender differences in the impact of adiposity on diabetes.Conclusion: In older Chinese, BMI-Asian/Hong Kong criteria is a better predictor of diabetes than other BMI criterion. Its combination with WC-China improved the prediction of adiposity to diabetes, which would help manage bodyweight in older age to reduce the risk of diabetes.
Funder
Royal Society of UK
Bupa Foundation
Alzheimer’s Research UK
Guangdong Medical University
Basic and Applied Basic Research Foundation of Guangdong Province Regional Joint Fund Project
Publisher
Korean Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism
Cited by
2 articles.
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