Abstract
Background: Fibrates have renal toxicity limiting their use in subjects with chronic kidney disease (CKD). However, pemafibrate has fewer toxic effects on renal function. In the present analysis, we evaluated the effects of pemafibrate on the renal function of diabetic subjects with or without CKD in a real-world clinical setting.Methods: We performed a sub-analysis of data collected during a multi-center, prospective, observational study of the effects of pemafibrate on lipid metabolism in subjects with type 2 diabetes mellitus complicated by hypertriglyceridemia (the PARM-T2D study). The participants were allocated to add pemafibrate to their existing regimen (ADD-ON), switch from their existing fibrate to pemafibrate (SWITCH), or continue conventional therapy (CTRL). The changes in estimated glomerular filtration rate (eGFR) over 52 weeks were compared among these groups as well as among subgroups created according to CKD status.Results: Data for 520 participants (ADD-ON, <i>n</i>=166; SWITCH, <i>n</i>=96; CTRL, <i>n</i>=258) were analyzed. Of them, 56.7% had CKD. The eGFR increased only in the SWITCH group, and this trend was also present in the CKD subgroup (<i>P</i><0.001). On the other hand, eGFR was not affected by switching in participants with severe renal dysfunction (G3b or G4) and/or macroalbuminuria. Multivariate analysis showed that being older and a switch from fenofibrate were associated with elevation in eGFR (both <i>P</i><0.05).Conclusion: A switch to pemafibrate may be associated with an elevation in eGFR, but to a lesser extent in patients with poor renal function.
Funder
Kowa Pharmaceutical Co. Ltd.
Novo Nordisk Pharma and Sumitomo Pharma Co. Ltd.
Ichiro Sakuma received research grants from Kowa Pharmaceutical Co. Ltd.
Mitsubishi Tanabe Pharma Corporation
Daiichi Sankyo Company
MSD
Novo Nordisk Pharma
Novartis Pharma
AstraZeneca
Life Scan Japan
Taisho Pharmaceutical Co. Ltd.
Astellas Pharma Inc.
Takeda Pharmaceutical Co. Ltd.
Chugai Pharmaceutical Co. Ltd.
Daiichi Sankyo Co. Ltd.
Otsuka Pharmaceutical Co. Ltd.
Pfizer Inc.
Alexion Inc.
Ono Pharmaceutical Co. Ltd.
Teijin Pharma Ltd.
AbbVie Inc.
Eisai Co. Ltd.
Bristol-Myers Squibb Co.
UCB Japan Co. Ltd.
Eli Lilly Japan K.K.
Kyowa Kirin Co. Ltd
AstraZeneca plc.
Medical and Biological Laboratories Co. Ltd.
Nippon Boehringer Ingelheim Co. Ltd.
Publisher
Korean Diabetes Association
Cited by
1 articles.
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