KARACİĞER İSKEMİ VE REPERFÜZYON HASARINDA KALP DOKUSUNDA MEYDANA GELEN HASARIN ÖNLENMESİNDE TAKSİFOLİN’İN KORUYUCU ETKİNLİĞİ: DENEYSEL ÇALIŞMA

Author:

BİLGE Hüseyin1ORCID,YILDIZHAN İbrahim2ORCID,ÜLGER Burak Veli3ORCID,ADAY Ulaş3ORCID,BAŞOL Ömer1ORCID,ÇİÇEKÇİ Kadriye3ORCID,YİLDİZHAN Eda3ORCID

Affiliation:

1. UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF GENERAL SURGERY

2. IGDIR UNIVERSITY, IĞDIR FACULTY OF AGRICULTURE, AGRICULTURAL BIOTECHNOLOGY

3. DICLE UNIVERSITY, SCHOOL OF MEDICINE

Abstract

Aim: Liver ischemia and reperfusion (I/R) is a serious, irreversible health problem in clinical practice. Taxifolin (Tax) is an easy to obtain and use agent found in maritime pine bark, Douglas fir bark and Siberian larch wood. In this study, we examined the protective efficacy of Taxifolin in the correction of cardiac tissue damage that may develop in liver I/R damage. Methods: In our study, a total of 28 Wistar Albino rats, 8-10 weeks old, weighing 250-300 grams, were used. Group 1 (n=7): control group, Group 2 (n=7): Tax group with 50 mg/kg dose orally for 3 weeks, Group 3 (n=7): Liver I/R group for 30 minutes ischemia and 120 minutes of reperfusion were performed. Group 4 (n=7): Tax+Liver I/R group. Results: In our study, MDA analysis was performed to evaluate oxidative stress. In the statistical analysis of MDA values, we observed that there was a statistically significant difference between the serum MDA values of the Tax group and the Tax+Liver I/R group, and the MDA level of the Tax group was lower (p<0.05). In myocyte damage scoring, we observed that the liver I/R group had the highest damage score, while the damage score of the Tax+Liver I/R group was significantly lower than the I/R group (p<0.05). Conclusion: As a result of our study, we observed that there was an increase in serum MDA levels as a result of liver I/R and histopathological changes occurred in the heart tissue. However, Taxifolin has been successful in ameliorating this situation.

Publisher

Cukurova Anestezi ve Cerrahi Bilimler Dergisi

Subject

General Materials Science

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