Evaluation of the efficacy of pretreatment chest CT markers in predicting response to neoadjuvant chemoradiotherapy in locally advanced non-small cell lung cancer (NSCLC)

Abstract

Aim: To investigate baseline enhanced chest CT findings that may predict progression or response to neoadjuvant chemoradiotherapy. Materials and methods: Multiple parameters to be obtained from baseline enhanced chest CT scans of 140 patients with NSCLC who had baseline enhanced chest CT scans before neoadjuvant chemoradiotherapy were noted. In addition to CT features of tumour tissues, age, gender, tumour cell types, lymph node TNM stages, distant metastases on baseline enhanced chest CT, bronchial and vascular invasion were also evaluated. Chest CT findings and changes in tumour tissue at 3 and 6 months during neoadjuvant treatment were noted. Patients were operated after the end of neoadjuvant treatment. It was investigated which parameters could predict response to neoadjuvant treatment and which findings could predict progression. Results: Progression and mortality rates were found to be low in patients with remission (p