Author:
Gorbulenko Natalia, ,Shokol Tetyana,Khilya Volodymyr, ,
Abstract
Heterocycle modified chromones are attracting increasing attention as novel potential therapeutic agents due to their effective bioactivities and low toxicity. This review describes all strategies and versatile synthons that have been developed for the synthesis of isoflavone heterocyclic analogs containing isolated 5-member heterocyclic rings with three identical or different heteroatoms. Their biological activity is also presented.
Publisher
Taras Shevchenko National University of Kyiv
Reference52 articles.
1. 1. Keri R, Budagumpi S, Pai R, Balakrishna R. Chromones as a privileged scaffold in drug discovery: A review. European Journal of Medicinal Chemistry 2014;78:340-374. https://doi.org/10.1016/j.ejmech.2014.03.047
2. 2. Gaspar A, Matos M, Garrido J, Uriarte E, Borges F. Chromone: A Valid Scaffold in Medicinal Chemistry. Chemical Reviews 2014;114(9):4960-4992. https://doi.org/10.1021/cr400265z
3. 3. Gorbulenko NV, Khilya VP. Synthesis and biological properties of isoflavonoids modified with nitrogen-containing heterocycles. Ukr. Chem. Journal. 1994;60(1):79-91.
4. 4. Parsons JH, Hunt RG, Leach SE, Perci A, Buss AD, GreenDE, Mellor M, inventor; Waldman RD et al Schering Agrochemicals Limited Industrial Property Department Chesterford Park assignee. Benzoheterocyclic fungicides. EP 0247760 A2. 1987 02.12 (Bulletin 87/49).
5. 5. Wang W, Zhang S, Wang J, Wu F, Wang T, Xu G. Bioactivity-Guided Synthesis Accelerates the Discovery of 3-(Iso)quinolinyl-4-chromenones as Potent Fungicide Candidates. Journal of Agricultural and Food Chemistry 2020;69(1):491-500. https://doi.org/10.1021/acs.jafc.0c06700
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