Pharmacokinetics Of Chitosan-Ethacridine Adduct In Rats

Author:

Antonyuk V.O.1,Manko N.O.2,Nektegaev I.O.1,Stoika R.S.1

Affiliation:

1. Danylo Halytsky Lviv National Medical University

2. NAS Ukraine

Abstract

The objective of this study is to investigate the pharmacokinetics of the chitosan-ethacridine adduct in white rats. It was demonstrated that the kinetics of ethacridine release from adduct are significantly different from that for intraperitoneally introduced ethacridine. When free ethacridine was introduced, 80% of the administered amount was detected in blood of rats in 30 min. This quantity decreased gradually until 20 h, when 1.25% of the administered amount was detected. Contrary, for chitosan-ethacridine adduct, the ethacridine content in the blood slowly increased for 8 h and then decreased. Even after 72 h of the injection, 3% of the injected amount of ethacridine was detected. The experiment demonstrates a significant delay in the release of ethacridine from the chitosan-ethacridine adduct in the blood of treated rats. Thus, a possibility of using chitosan for prolongation of action of the ethacridine as an antiseptic agent was shown.

Publisher

Taras Shevchenko National University of Kyiv

Subject

Analytical Chemistry

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. CHITOSAN ADDUCT WITH TRANEXAMIC ACID AND ITS HAEMOSTATIC EFFECT;Progress on Chemistry and Application of Chitin and its Derivatives;2022-09-30

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3