Affiliation:
1. National University of Pharmacy
Abstract
The oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Prochlorperazine Maleate is presented. Potassium hydrogen peroxymonosulfate as a derivatizing agent, yielding the Prochlorperazine sulfoxide with λmaх=338 nm is proposed. This reaction product was successfully employed for the spectrophotometric determination of the Prochlorperazine Maleate. The UV spectrophotometric determination of Prochlorperazinе as its sulfoxide proved to be the more robust and selective method. Concentration dependence of the oxidation product remains linear in the range of concentrations from 2 to 40 μg∙mL-1. Limit of quantification (LOQ) is 1.7 μg·mL-1. A new spectrophotometric technique was developed and the possibility of quantitative determination of Prochlorperazine Maleate in 5 mg Vetrinex tablets was demonstrated. The present method is precise and accurate. The common excipients employed do not interfere in the determination. Results of analysis of the tablet dosage form by the proposed method are in good agreement with those of the official method. RSD = 1.34 % (δ = ± 0.57 %).
Publisher
Taras Shevchenko National University of Kyiv
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