Analysis of functional changes under using of candesartan cilexetil with resveratrol in animals

Abstract

Cardiovascular diseases are widespread throughout the world. The incidence of diseases of the cardiovascular system has increased several times. Cardiovascular diseases have become the leading cause of death in many countries. Currently, the efforts of many researchers are aimed at studying and creating new, more effective and safe drugs and their combinations for the treatment of pathology of the cardiovascular system. Candesartan cilexetil is an angiotensin II receptor antagonist. It is used medicinally as a long-acting antihypertensive agent. However, this drug has a number of side effects. Resveratrol is a natural antioxidant. This substance exhibits pleiotropic effects, including antioxidant, anti-inflammatory, anti-aging, cardioprotective, and neuroprotective activities. The aim is investigation of acute toxicity of candesartan cilexetil and resveratrol in combination in vivo. Male and female ICR mice were used for the experiment. Animals received candesartan cilexetil and resveratrol intragastrically once. Evaluation of the effects of substances on internal organs (heart, spleen, kidneys, lungs, liver and brain) was carried out in 2 weeks after the introduction of the substances. It was shown that candesartan cilexetil with natural resveratrol did not lead to functional changes. There were no changes of behavior during the observation period. The combination of candesartan cilexetil with resveratrol did not lead to the death of mice, therefore the mean lethal dose (LD50) was not determined. The new combination of substances was safe. No side effects have been reported. The combination of candesartan cilexetil with resveratrol is non-toxic, and the use of these substances is safe for animals.