Water transport through rat colonic epithelium during ceftriaxone therapy-Reference-Cited by-同舟云学术

Water transport through rat colonic epithelium during ceftriaxone therapy

Published:2014 Issue:3 Volume:68 Page:29-33
ISSN:1728-2748
Container-title:Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology
language:
Short-container-title:BTSNUKSB

Author:

Dovbynchuk T.¹,Beregova T.¹,Tolstanova H.¹,Zakordonets L.²

Affiliation:

1. Taras Shevchenko National University of Kyiv

2. O.O. Bogomolets National Medical University

Abstract

The dose and time-depended effect of the antibiotic ceftriaxone on net water transport in rat colonic epithelium was studied by colonic loop perfusion technique in situ. Ceftriaxone in dose 50 mg / kg / day caused diarrhea in 10% of rats, in dose 300 mg/kg/day – 25% of rats. Ceftriaxone in both doses decreased net water absorption in rat colon. The resulting effect was more pronounced after 14-days course compared with 5-days.

Publisher

Taras Shevchenko National University of Kyiv

Subject

Applied Mathematics,General Mathematics

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