Protein kinase C participation in the mechanisms of vascular tone disturbance upon diabetes mellitus. Part 4

Abstract

Diabetes mellitus (DM) is acompaining by vascular tone desorders development. Regulatory enzyme protein kinase C (PKC) is involved in mechanisms of these desorders development. Numerous studies have demonstrated that contractile responces of vascular smooth muscle are enchansed in DM and endothelium-independent PKC-mediated mechanisms are involved in this process. Such mechanisms are PKC-mediated inhibition of Ca2+ activated K+ channels (BKCa) in vascular smooth muscle cells (SMCs) and SMCs myophilaments Ca2+ sensitization. PKC is a potential therapeutic target for treating vascular diabetic complications. A few compounds among PKC inhibitors already exist, such as ruboxistaurin, indolylmaleimide and its derivatives. Recently discovered method of RNA-interference (RNAi) is an essential gene-silencing tool and can also be used for PKC inhibition and DMassociated vascular complicaions elimination.