Oxidation-antioxidant balance in the colon mucosa of rats at different times points after ceftriaxone administration-Reference-Cited by-同舟云学术

Oxidation-antioxidant balance in the colon mucosa of rats at different times points after ceftriaxone administration

Published:2017 Issue:1 Volume:22 Page:11-15
ISSN:1728-2624
Container-title:Bulletin of Taras Shevchenko National University of Kyiv. Series: Problems of Physiological Functions Regulation
language:
Short-container-title:BTSNUKSPPFR

Author:

Holota Y.¹,Bazan A.¹,Tolstanova G.¹

Affiliation:

1. Taras Shevchenko National University of Kyiv

Abstract

Сeftriaxone administration for 14 days (300 mg/kg, i.m.) increased level of thiobarbituric acid reactive substances and decreased the activity of superoxide dismutase and catalase antioxidant enzymes in the colon mucosa of rats immediately after antibiotics injection. On the 29th day of the experiment (in 14 days after ceftriaxone withdrawal) the level of TBA-active substances still 2.5-fold (P <0.05) exceeded the control value and SOD activity remained below control values to the 72nd day of the experiment. These were accompanied by decreased level of protein thiol groups in 15 and 29 days 1.9-fold (P <0.05) and 1.4-fold (P = 0.08), respectively. Thus antibiotics can lead to long-term oxidative disturbance in the colon mucosa of rats.

Publisher

Taras Shevchenko National University of Kyiv

Subject

General Medicine,General Chemistry

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