Directions and Essential Experimental Findings of Statin Treatment in Diabetic Patients

Abstract

The purpose of conducted study was to determine which of the different types of statins ensure a better control of biological markers in diabetic patients and which of the lipid molecules studied, could be a first choice of lipid-lowering therapy in people suffering from diabetes. The measurement of blood glucose levels depending on type of statin used, was another target of this research. Dyslipidemia was a major risk factor for cardiovascular complications in people with diabetes. According to ROC statistical analysis it was found that Atorvastatin was the most effective statin in controlling dyslipidemia in diabetic patients, because has ensured optimum control of HDL, LDL - cholesterol, triglycerides and glycemic values, effect which was resulted from the particular chemical structure of Atorvastatin. Atorvastatin was discovered to be the best predictor in diabetes mellitus type 2 treatment, with a sensitivity about 78% and specificity to 45%., the most highest values compared to Rosuvastatin and Simvastatin. Area Under the Curve (AUC = 0.610; AUC ˃ 0.600)