Affiliation:
1. Voronezh State Medical University named after N.N. Burdenko; Department of Health of the Voronezh Region
2. Voronezh State Medical University named after N.N. Burdenko
Abstract
Introduction. Iron-deficiency accompanies many diseases, including cardiovascular pathology, so timely diagnosis and correction of this condition is necessary.Aim. To study the features of the course of stable exertional angina against the background of iron deficiency anemia before and after correction with iron (III) polymaltose hydroxide in patients in primary health care using a computerized patient register.Materials and methods. 1210 patients with stable exertional angina aged 50–85 years (309 men, 901 women) were included. A special computer program was created for data analysis. In 500 out of 1210 patients, IDA was detected (385 women, 115 men). Mild anemia – 410 patients, moderate – 75, severe – 15. The main group – patients with stable exertional angina and Irondeficiency anemia (the first subgroup – patients treated with iron (III) polymaltose hydroxide and the second subgroup – patients who did not receive the drug iron (III) polymaltose hydroxide due to refusal of treatment or contraindications) and the control group – patients with stable exertional angina without Iron-deficiency anemia. All patients received standard therapy recommended for the treatment of stable exertional angina (the main group additionally received iron (III) polymaltose hydroxide).Results. In the first subgroup of the main group, after treatment with iron (III) hydroxide polymaltose, there was a statistically significant increase in hemoglobin levels by 11,7%, hematocrit by 5%, erythrocytes by 4%, serum iron by 112,8%, and an improvement in exercise tolerance by 48,7%, episodes of ST segment depression by 30,2%. In the second subgroup and the control group, there were no significant changes in the above parameters.Conclusion. Iron-deficiency anemia contributes to the severe course of stable exertional angina, which is confirmed by the high frequency of III-IV functional class exertional angina, a decrease in tolerance to exercise stress. Correction of Iron-deficiency anemia reduces the frequency of episodes of transient myocardial ischemia in the main group.
Reference35 articles.
1. Vyortkin A.L., Khovasova N.O., Laryushkina Ye.D., Shamayeva K.I. Anemia in ambulatory practice. Effective Pharmacotherapy. 2014;8(1):6–9. (In Russ.) Available at: https://umedp.ru/articles/anemiya_u_ambulatornogo_bolnogo.html?ysclid=lazik1ed98421950399.
2. Schop A., Kip M.M., Stouten K., Dekker S., Riedl J., van Houten R.J. et al. The effectiveness of a routine versus an extensive laboratory analysis in the diagnosis of anemia in general practice. Ann Clin Biochem. 2018;55(5):535–542. https://doi.org/10.1177/0004563217748680.
3. Brooke E.M. The current and future use of registers in health information systems. Geneva: World Health Organization; 1974. 43 p. Available at: https://apps.who.int/iris/handle/10665/36936.
4. Martsevich S.Yu., Semenova Yu.V., Kutishenko N.P., Zagrebelniy A.V., Ginzburg M.L. Assessment of patients compliance for ambulatory institutions visits and its influence on the quality of treatment before development of acute coronary syndrome, by the LIS-3 registry. Russian Journal of Cardiology. 2016;21(6):55–60 (In Russ.) https://doi.org/10.15829/15604071-2016-6-55-60.
5. Sadykova K.Z., Shalkharova Z.S., Shalkharova Z.N., Nuskabayeva G.O., Sadykova A.D., Zhunissova M.B. et al. Prevalence of anemia, its socio-demographic determinants and potential association with metabolic syndrome in residents of Turkestan, southern Kazakhstan. Ekologiya Cheloveka (Human Ecology). 2015;22(8):58–64 (In Russ.) https://doi.org/10.17816/humeco17010.