Affiliation:
1. Omsk State Medical University
2. Dr. Reddy’s Laboratories
Abstract
Introduction. Functional dyspepsia (FD) is a multifactorial disease, and the combination of drugs with different mechanisms of action makes it possible to optimally influence various parts of the pathogenesis.Aim. Prospective observational study TANDEM evaluated the efficacy and tolerability of omeprazole and domperidone fixed combination therapy in the treatment of functional dyspepsia in patients with chronicHelicobacter pylorinegative gastritis after 4 weeks course of treatment.Materials and methods. In accordance with the purpose of the study, a study cohort was formed of 50 patients with symptoms of functional dyspepsia (30 men, 20 women). The mean age was 29.06 (25.88–32.25). Efficacy and tolerability were assessed using the Visual Analog Scale and the Likert scale.Results. The study was completed by 47 patients. After 4 weeks of treatment, positive dynamics in the form of complete relief of symptoms was noted in all 47 patients; no clinically significant changes in the QT interval were detected.Conclusion. Evaluation of the efficacy of fixed combination omeprazole and domperidone in the treatment of functional dyspepsia in patients with chronicHp-negative gastritis demonstrated 100% efficacy of the drug in relieving symptoms 4 weeks after the start of therapy. After 72 hours from the start of the treatment, the effect in the form of complete relief of symptoms was registered in 87.25% of patients. On the 14th day the symptoms were completely relieved in 95.74% of patients. Assessment of tolerability demonstrated a good safety profile of the drug, in particular, the absence of clinically significant changes in the QTс interval.
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