Gut microbiota as one of the key regulators of metabolic diseases

Abstract

Introdiction. The presence of obesity in a patient or, conversely, malnutrition is accompanied by various metabolic disorders and is the focus of modern medical science and healthcare organizers.Objective. To reveal the mechanism of action (impact on motility through the intestinal microbiota) of the drug mebeverine in the structure of concomitant therapy for IBS.Material and methods. The index of nutritional insufficiency was proposed and calculated by us on the basis of the parameters of the alimentary-volemic diagnosis, expressed in points; up to 29 points – a mild degree of nutritional deficiency (the risk of surgery is minimal, the operation is possible after a short-term infusion preparation); 29–30 points – medium degree (the risk is relatively high, the operation is possible only after at least minimal preliminary infusion-alimentation correction); 31–33 – severe degree of nutritional insufficiency (the risk of surgery is high, surgery can only be performed in an emergency after minimal preparation or planned after a long preparation of the patient for surgery until the nutritional status is increased by 1–2 levels; 34–42 – extremely severe (only emergency surgery or palliative after preliminary preparation, raising, if possible, the nutritional status by 1–2 levels).Rehabilitation potential was determined according to generally accepted formulas. Microbiota was also determined by the traditional method. Electrical activity and the nature of motility were determined by it using a mingograph.Results and discussion. During the examination, it was revealed that the microbiota differs with different HN. At 29–30 points, HH and high RR occur. Rehabilitation potential (RP) has 4 levels of assessment: High rehabilitation potential implies the possibility of achieving a full recovery of healthConclution. Gut microbiota is a key regulator of metabolic disease. When taking mebeverine, it is advisable. Apparently, to apply a detoxification correction, because it is metabolized in the liver. There is no doubt that it is expedient to further study the state of the microbiota in the modern world with various TIN.