Vestibulo-atactic disorders correction in chronic brain ischemia

Abstract

Introduction. Chronic brain ischemia (CBI) is one of the most common causes of vestibulo-atactic disorders and cognitive impairment in the elderly.Objective. To investigate the effectiveness of Vinpotropil we trail in the treatment of patients with CBI.Materials and methods. The open-label, comparative, randomized study included 60 patients, 24 men and 36 women, aged 40 to 72 years (mean age – 52.8 ± 7.7 years), with CBI. The cause of the disease was atherosclerosis of the cerebral vessels (16 people), hypertension (11 people) and their combination (33 people). During 2 months together with a basic therapy (antihypertensive, hypolipidemic therapy – as in-dicated) patients of group 1 (30 people) had been taken betagistine 24 mg x 2 r/day; group 2 (30 people) – Vinpotropil 1 caps x 3 r/day in combination with Betagistin Canon 24 mg x 2 r/day. Results and discussion. As a result of the treatment, there was a decrease in the severity of vertigo from 2.9 ± 0.3 points at the beginning of the study, to 2.1 ± 0.3 (group 1) and 1.4 ± 0.4 points (group 2), p < 0.05. The average score on the MoСА test was 27.3 ± 0.8 at the beginning of treatment, and by its end significantly increased in patients of both groups, amounting to 28.7 ± 0.6 and 29.2 ± 0.5 (p < 0.05).Conclusion. The data obtained indicate that the administration of Vinpotropil in addition to Betahistine Canon allowed to achieve more pronounced results of therapy.