Affiliation:
1. Kazan Federal University
Abstract
The review examines the role of mometasone furoate (NSMF) intranasal spray (Nasonex) in the treatment of allergic rhinitis (AR). There is a wide prevalence of AR both among children and adults, its adverse effect on the quality of life of patients. It is emphasized that the main means of therapy for moderate and severe course in accordance with international and Russian recommendations for the diagnosis and treatment of AR are intranasal glucocorticosteroids (INGKS). The pharmacological features of the MF molecule that underlie its efficacy and safety, including the affinity, lipophilicity and viscosity of the drug, as well as low systemic bioavailability, are discussed in detail. The therapeutic effects of NSMF in the treatment of seasonal and perennial AR, its effect on nasal symptoms are discussed in detail. The beneficial effect of NSMF therapy on nasal congestion is emphasized separately. The beneficial effect of NSMF treatment on other clinical manifestations of AR, including ocular symptoms, effects on sleep, and olfactory function, has been noted. The safety issues of NSMF use are discussed in detail, including systemic effects, such as effects on adrenal function, eye, and growth retardation in children, and local adverse effects on the nasal mucosa; there is a high profile of local and systemic safety of long-term use of NSMF in the treatment of AR in both adults and children.
Reference52 articles.
1. Astafeva N.G., Baranov A.A., Vishneva E.A., Daykhes N.A., Zhestkov A.V., Il’ina N.I. et al. Allergic rhinitis: clinical guidelines. Moscow; 2020. 84 p. (In Russ.) Available at: https://raaci.ru/dat/pdf/allergic_rhinitis.pdf.
2. Bousquet J., Khaltaev N., Cruz A.A., Denburg J., Fokkens W.J., Togias A. et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2) LEN and AllerGen). Allergy. 2008;63(s86):8–160. https://doi.org/10.1111/j.1398-9995.2007.01620.x.
3. Bousquet P.J., Demoly P., Devillier P., Mesbah K., Bousquet J. Impact of Allergic Rhinitis Symptoms on Quality of Life in Primary Care. Int Arch Allergy Immunol. 2013;160(4):393–400. https://doi.org/10.1159/000342991.
4. Muliol J., Maurer M., Bousquet J. Sleep and allergic rhinitis. J Investig Allergol Clin Immunol. 2008;18(6):415–419. Available at: https://pubmed. ncbi.nlm.nih.gov/19123431/
5. Jáuregui I., Mullol J., Dávila I., Ferrer M., Bartra J., del Cuvillo A. et al. Allergic rhinitis and school performance. J Investig Allergol Clin Immunol. 2009;19(1 Suppl.):32–39. Available at: https://pubmed.ncbi.nlm.nih.gov/19476052/
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献