Affiliation:
1. National Research Center – Institute of Immunology
2. Pacific State Medical University
Abstract
Bronchial asthma is the most common chronic disease of children, the worst way is their quality of life. Compliance in the treatment of children is very important, since the actual effect of a drug is determined by both the effective drugs and patient adherence and correct use. A relevant test is the use of mild asthma, which is able to control bronchial hyperreactivity associated with exercise, cold air, and other nonspecific irritants (smoke, odors, etc.). Planning of baseline therapy for children with mild asthma aged 5 years old and younger is particularly problematic for paediatricians due to high incidences of acute respiratory viral diseases and viral-induced exacerbations of bronchial asthma among them. In these children, allergen-specific immunotherapy, long-acting B-agonists, the use of many metered-dose inhaled glucocorticosteroids. are not recommended.Montelukast, an oral antileukotriene drug, has advantages in the treatment of children with mild asthma with virus-induced exacerbations, with asthma of physical exertion and severe bronchial hyperreactivity, especially when combined with allergic rhinitis, as well as in special clinical cases, when parents refuse to use ICS for treatment children with mild asthma or inability to use them for some reason. The use of montelukast for mild asthma in children in the current context of the COVID-19 pandemic also has advantages that pediatricians can use when observing these children in the pediatric area, taking into account contraindications.
Reference48 articles.
1. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211–1259. doi: 10.1016/S0140-6736(17)32154-2.
2. de Benedictis F.M., Attanasi M. Asthma in childhood. Eur Respir Rev. 2016;25(139):41–47. doi: 10.1183/16000617.0082-2015.
3. Karaulov A.V., Garib V., Garib F., Valenta R. Protein Biomarkers in Asthma. Int Arch Allergy Immunol. 2018;175(4):189–208. doi: 10.1159/000486856.
4. Matricardi P.M., Kleine-Tebbe J., Hoffmann H.J., Valenta R., Hilger C., Hofmaier S. et al. EAACI Molecular Allergology User’s Guide. Pediatr Allergy Immunol. 2016;27(23 Suppl.):1–250. doi: 10.1111/pai.12563.
5. Sourovenko T.N., Zgeleznova L.V. Domestic acarofauna and allergic airways inflammation. Allergologiya = Allergology. 2003;(1):11–14. (In Russ.) Available at: https://elibrary.ru/item.asp?id=9120103.