Affiliation:
1. Pirogov Russian National Research Medical University; Sverzhevsky Scientific and Research Otolaryngology Clinical Institute
2. Pirogov Russian National Research Medical University
Abstract
The article provides data on the effectiveness of the use of the drug in the treatment of acute, chronic and recurrent diseases of the respiratory tract and ENT organs. The drug is an extract of Pelargonium sidoides. From the standpoint of modern pharmacology, it is known that the use of natural products based on plant materials ensures safety and the absence of pronounced side effects. The main active ingredients of pelargonium are phenolic compounds: coumarins, flavonoids and phenolic acids. The article details the biochemical and pharmacological properties of each of the above groups of compounds. It has been shown that the presence of several classes of phenolic compounds simultaneously contributes to the potentiation of the pharmacological effects of each group separately. Therefore, drug has a pronounced polytropic effect: antiviral, antibacterial, immunomodulatory, mucolytic, anti-inflammatory, antioxidant, cytoprotective. The article presents the results of numerous domestic and foreign randomized, placebo-controlled studies demonstrating its high efficacy and safety in the treatment of ENT diseases, upper respiratory tract infections and bronchitis, not only in adults, but also in children over 1 year old. On the basis of the analyzed and presented material, the authors concluded that the use of a natural-based drug in the treatment of acute respiratory infection is effective and safe, both as monotherapy and in combination with other medicinal substances. He is able to quickly eliminate not only the symptoms of inflammation, but also to support the body with any ailments of this type.
Reference33 articles.
1. Pelucchi C., Grigoryan L., Galeone C., Esposito S., Huovinen P., Little P., Verheij T. Guideline for the management of acute sore throat. Clin Microbiol Infect. 2012;18(1 Suppl.):1-28. https://doi.org/10.1111/j.1469-0691.2012.03766.x.
2. Kryukov A.I., Gurov A.V., Yushkina M.A., Izotova G.N., Sokolov S.S. Peculiarities of antibacterial therapy of purulent and inflammatory pathology of ENT-organs. Meditsinskiy sovet = Medical Council. 2016;(18):18-22. (In Russ.) https://doi.org/10.21518/2079-701X-2016-18-18-22.
3. Kurkin V.A. Fundamentals of herbal medicine. Samara: Ofort, SamSMU; 2009. 963 p. (In Russ.).
4. Kiseleva T.L., Dronova M.A. Synergistic aspects of modern phytopharmacology. Novosti meditsiny i farmatsevtiki = News of Medicine and Pharmaceuticals. 2012;(7). (In Russ.) Available at: http://www.mif-ua.com/archive/article/28906.
5. Kiseleva T.L., Smirnova Yu.A., Blinkov I.L., Dronova M.A., Tsvetaeva E.V. A short encyclopedia of modern herbal medicine with the basics of homeopathy: a practical doctor's guide. Moscow: Professional Association of Naturotherapists; 2010. 592 p. (In Russ.).