Affiliation:
1. Karaganda Medical University; Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
2. Karaganda Medical University
3. Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Abstract
The article dedicates to the study of microelements in the blood serum of women of reproductive age, with newly diagnosed hypothyroidism (subclinical and manifest), living in disadvantaged areas of the Aral Sea region. This article presents the study of 1154 women. Every fourth woman (25%) has an essential deficiency of such microelements like iodine, selenium, iron, zinc independently of thyroid function. Our study discovered negative associations of TSH concentration with essential microelements like manganese, copper, selenium, and positiveassociation with iodine. We also obtain positive relationships between AT-TPO and zinc and iodine. The relationship of zinc with AT – TPO level and thyroid status, especially in the regions with sufficient ioduria among residents,require further researchto study it’spossible effecton thyroid dysfunctions. We established positive associations of free T4 with essential microelements like manganese, iron, and negative association with iodine. Estimation of thyroid status and toxic microelementsrevealed positive association of free T4 with cadmium, nickel, and lead, and negativewith mercury.
Reference38 articles.
1. Никитин Ю.П., Рымар О.Д., Мустафина С.В., Симонова Г.И., Малютина С.К., Рябиков А.Н. и др. Обеспеченность йодом взрослого насе- ления Новосибирска. Вопросы питания. 2008;2(77):64–66. Nikitin Yu.P., Rymar O.D., Mustafina S.V., Simonova G.I., Malyutina S.K., Ryabikov A.N., et al. Providing of adult population of Novosibirsk with iodine. Voprosy pitaniya = Problems of Nutrition. 2008;2(77);64–66. (In Russ.)
2. Агаджанян А., Скальный А. В., Детков В. Ю. Элементный портрет человека: заболевае- мость, демография и проблема управления здоровьем нации. Экология человека. 2013;(11):3-12. Agadzhanyan N.A., Skalny A.V., Detkov V.Yu. Human elemental portrait: morbidity, demography and problem of nation health management. Ekologiya cheloveka = Human Ecology. 2013;(11):3–12.(In Russ.)
3. Boas M., Feldt-Rasmussen U., Skakkebaek N.E., Main K.M. Environmental chemicals and thyroid function. Eur J Endocrinol. 2006;154(5):599–611. doi: 10.1530/eje.1.02128.
4. Pearce E.N., Braverman L.E. Environmental pollutants and the thyroid. Best Pract Res Clin Endocrinol Metab. 2009;23(6):801–813. doi: 10.1016/j.beem.2009.06.003.
5. Dundar B., Oktem F., Arslan M.K., Delibas N., Baykal B., Arslan C., et al. The effect of longterm low-dose lead exposure on thyroid function in adolescents. Environ Res. 2006;101(1):140–145. doi: 10.1016/j.envres.2005.10.002.
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