Affiliation:
1. Federal State Budgetary Institution «Research Institute for Complex Issues of Cardiovascular Diseases»; Federal State Budgetary Educational Institution of the Higher Education «Moscow State University of Medicine and Dentistry named after A.I. Yevdokimov» of the Ministry of Healthcare of the Russian Federation.
2. Federal State Budgetary Institution «Research Institute for Complex Issues of Cardiovascular Diseases».
3. State Budgetary Healthcare Institution of Kemerovo Region «Barbarash Kemerovo Regional Clinical Cardiological Dispensary».
4. Federal State Budgetary Institution «Research Institute for Complex Issues of Cardiovascular Diseases»; State Budgetary Healthcare Institution of Kemerovo Region «Barbarash Kemerovo Regional Clinical Cardiological Dispensary».
Abstract
Purpose: to identify the factors associated with the development of death events during the year follow-up after hospitalization for pulmonary embolism (PE). Materials and methods: 93 patients with PE discharged to the outpatient stage of observation were studied. 45 (61,6%) patients were female with an average age of 66 years. The examination of patients at the stage of inclusion in the study consisted of standard methods of examination for this pathology. The diagnosis was confirmed by multislice computed tomography. Follow-up was 12 months. Statistical analysis was performed using the MedCalc Version 16.2.1. Results: during the one-year follow-up period 62 (66,7%) patients with PE were alive but 11 patients (11,8%) died, and no information was obtained about 20 patients. The causes of death were as follows: the development of recurrent PE – 4 (36,4%) patients, cancer – 3 patients (27,3%), stroke – 2 (18,1%), one patient (9,1%) died due to severe heart failure and one – myocardial infarction. A comparative analysis in the groups of alive patients (n = 62) and patients with a fatal events (n = 11) showed that the dead patients were older (78 (68; 81) vs. 65 (49; 75) years; p = 0,003), had a higher PESI score (119,0 (99,7; 137,2) vs. 88,0 (68,0; 108,0); p = 0,016) and were less compliant to prolonged anticoagulant therapy during the one year of observation (45,5% of patients (n = 5) vs. 82,3% ( = 51); p = 0,015). The ROC curve determined that a high risk of death during the one year after PE is associated with age over 70 years (p = 0,0001) and more than 95 points by PESI in the hospital period (p = 0,0001). Conclusion: The death events were developed in 11,8% of cases in patients with pulmonary embolism during the first year of follow-up. The death outcomes were significantly associated with elderly age, intermediate and high risk by PESI in the hospital period and low compliance to anticoagulant therapy extended during the year after pulmonary embolism.
Reference20 articles.
1. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J. 2014 Nov 14;35(43):3033-69, 3069a-3069k. doi: 10.1093/eurheartj/ehu283.
2. Ermolaev A.A., Plavunov N.F., Spiridonova E.A., Stazhadze L.L. Pulmonary embolism: medical and demographic characteristics, pathophysiological features of the acute period, risk factors. Tromboz, Gemostaz i Reologia. 2011;2(46):25-33. (In Russ).
3. Berns S.A., Schmidt E.A., Nagirnyak O.A. Management of patients with pulmonary thromboembolism in a cardiological hospital from the perspective of current guidelines of the European Society of Cardiology. Kompleksnye Problemy Serdechno-Sosudistykh Zabolevaniy. 2015;(4):9096. https://doi.org/10.17802/2306-1278-20154-90-96. (In Russ).
4. Buryachkovskaya L.I., Lomakin N.V., Sumarokov AB, Shirokov E.A. Algorithms and scores for risk of thrombosis and hemorrhage in cardiology and neurology. Practical guide. 2018. p. 48. (In Russ).
5. Vasiltseva O.Ya., Vorozhtsova I.N., Lavrov A.G., Karpov R.S. Assessment of unfavourable prognosis factors in patients with pulmonary thromboembolism. Terapevtichesky Arkhiv. 2016;12:28-33. doi: 10.17116/terarkh2016881228-32. (In Russ).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献