Safety and tolerability of nsaids: focus on aceclofenac

Abstract

The article discusses the main problems of safety of non-steroidal anti-inflammatory agents (NSAIDs). The results of randomized clinical studies, pharmacoepidemiological studies and meta-analyses suggesting higher safety of aceclofenac compared to diclofenac and other widely used NSAIDs are presented. Special attention is paid to the new pharmaceutical form of aceclofenac – tablets with modified release, manufactured by Clanza technology, registered under the trade name Aceclagin. It is intended for a single injection per day, which allows to increase adherence to therapy.