Vaccinal prevention of chickenpox: relevance of the problem

Author:

Nikolaeva S. V.1ORCID,Pogorelova O. O.1,Khlypovka Yu. N.1ORCID,Gorelov A. V.2ORCID

Affiliation:

1. Central Research Institute of Epidemiology

2. Central Research Institute of Epidemiology; I.M. Sechenov First Moscow State Medical University (Sechenov University)

Abstract

Chickenpox is an acute viral infection which is a serious public health problem. According to the World Health Organization, there are 4,2 million severe forms of disease requiring hospitalization and 4,200 deaths annually. The CP cause is DNA-containing herpesvirus 3, Varicella-zoster. The first symptoms of the disease appear after the incubation period, which lasts from 10 to 21 days, and are manifested by fever, malaise and the appearance of a characteristic rash in the form of small vesicles with transparent content on the skin and mucous membranes. The vesicles are progressively covered with crust, which disappears within 7–10 days. Chicken pox is more frequent in the mild and moderate form, but it may develop severe forms, atypical course, complications (most often bacterial skin infections and lesions of the nervous system are registered in children (more often – chicken encephalitis), and in adults - pneumonia). Vaccinal prevention is the most effective and scientifically proven method of infection control, and chickenpox currently belongs to such infections. The currently used chickenpox vaccines were developed in the mid 1970s, used in some countries from the mid 1980s, and from the early 1990s began to be used in routine immunization programmes in leading countries. Since then, their safety and immunogenicity as well as high efficiency of routine chickenpox vaccine prevention in both healthy and high-risk individuals have been proved. Accumulated experience has shown that a vaccine can reduce the number of cases and the frequency of hospitalizations and deaths when mass immunization is carried out.

Publisher

Remedium, Ltd.

Subject

General Medicine

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. ТЯЖЕЛОЕ ТЕЧЕНИЕ ВЕТРЯНОЙ ОСПЫ У РЕБЕНКА ТРЕХ ЛЕТ. КЛИНИЧЕСКИЙ СЛУЧАЙ;Анализ проблем и поиск перспективных научных решений: сборник статей международной научной конференции (Санкт-Петербург, Февраль 2024);2024-03-22

2. The nature of lesions of the central nervous system in infections, caused by <i>Varicella Zoster</i> virus;CHILDREN INFECTIONS;2023-11-17

3. CHICKENPOX AND HERPES ZOSTER: DYNAMICS OF INCIDENCE AND APPROACHES TO PREVENTION;YAKUT MED J;2023

4. Varicella-pox virus infection: features of the course, clinical manifestations, complications, and possibilities for prevention;Terapevticheskii arkhiv;2021-11-15

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