Biological treatment of severe asthma: new objectives and new treatment options
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Published:2019-12-08
Issue:15
Volume:
Page:50-61
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ISSN:2658-5790
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Container-title:Medical Council
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language:
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Short-container-title:Medicinskij sovet
Affiliation:
1. Russian Medical Academy of Continuing Professional Education
Abstract
This article is devoted to the main characteristics of severe bronchial asthma (SBA) and its heterogeneity, in particular, T2 asthma is characterized and the role of the main cytokines forming T2-inflammation is presented. The main emphasis is made on the role of the IL-4 and IL-13 in the pathogenesis of AD as the key cytokines in the initiation and maintenance of T2-inflammation, as well as on a new biological molecule – monoclonal antibody – dupilumab, directed to the α-subunit of IL-4 receptor, thus blocking the pathways of IL-4 and IL-13. Dupilumab has recently been registered in our country for the treatment of moderate and severe BA, as well as moderate and severe atopic dermatitis. The article presents the clinical efficacy and tolerability of dupillumab in patients with moderate and severe BA.
Reference47 articles.
1. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2019. Available at: www.ginasthma.org. 2. Bousquet J., Mantzouranis E., Cruz A.A., AïtKhaled N., Baena-Cagnani C.E., Bleecker E.R., Brightling C.E., Burney P., Bush A., Busse W.W., Casale T.B., Chan-Yeung M., Chen R., Chowdhury B., Chung K.F., Dahl R., Drazen J.M., Fabbri L.M., Holgate S.T., Kauffmann F., Haahtela T., Khaltaev N., Kiley J.P., Masjedi M.R., Mohammad Y., O’Byrne P., Partridge M.R., Rabe K.F., Togias A., van Weel C., Wenzel S., Zhong N., Zuberbier T. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. 2010;126(5):926-938. doi: 10.1016/j.jaci.2010.07.019. 3. Chung K.F., Wenzel S.E., Brozek J.L., Bush A., Castro M., Sterk P.J., Adcock I.M., Bateman E.D., Bel E.H., Bleecker E.R., Boulet L.P., Brightling C., Chanez P., Dahlen S.E., Djukanovic R., Frey U., Gaga M., Gibson P., Hamid Q., Jajour N.N., Mauad T., Sorkness R.L., Teague W.G. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343-373. doi: 10.1183/09031936.00202013. 4. Aaron S.D., Vandemheen K.L., FitzGerald J.M., Ainslie M., Gupta S., Lemière C., Field S.K., McIvor R.A., Hernandez P., Mayers I., Mulpuru S., Alvarez G.G., Pakhale S., Mallick R., Boulet L.P. Canadian Respiratory Research Network. Reevaluation of diagnosis in adults with physician-diagnosed asthma. JAMA. 2017;317(3):269- 279. doi: 10.1001/jama.2016.19627. 5. GINA. Difficult-to-treat & severe asthma in adolescent and adult patients. Diagnosis and Management. V2.0 April 2019. Available at: https://ginasthma.org/wp-content/ uploads/2019/04/GINA-Severe-asthmaPocket-Guide-v2.0-wms-1.pdf.
Cited by
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