Why do acute respiratory infections in children remain a pressing problem? Current, prevention and treatment options-Reference-Cited by-同舟云学术

Why do acute respiratory infections in children remain a pressing problem? Current, prevention and treatment options

Published:2019-11-24 Issue:17 Volume: Page:198-206
ISSN:2658-5790
Container-title:Medical Council
language:
Short-container-title:Medicinskij sovet

Author:

Kanner E. V.¹^ORCID,Gorelov A. V.²^ORCID,Pechkurov D. V.³^ORCID,Maksimov M. L.⁴^ORCID,Ermolayeva A. S.⁵

Affiliation:

1. Federal State Institution of Science «Central Research Institute of Epidemiology of Rospotrebnadzor»

2. Federal State Institution of Science «Central Research Institute of Epidemiology of Rospotrebnadzor»; Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

3. Federal State Budgetary Educational Institution of Higher Education «Samara State Medical University of the Ministry of Health of the Russian Federation»

4. Kazan State Medical Academy, a branch of the Federal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuous Professional Education» of the Ministry of Health of the Russian Federation; Federal State Budgetary Educational Institution of Higher Education «Russian National Research Medical University named after N.I. Pirogov» of the Ministry of Health of the Russian Federation

5. Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Abstract

Literary data on peculiarities of immune system, anti-infectious immunity, including local protection of respiratory tract (lymphaticepithelial pharyngeal system), in children of early and preschool age, causing their higher incidence of acute respiratory infections (ARI) are given in the article. This age period is characterized by «physiological» humoral immune deficiency, reduced activation of the complement system, insufficient synthesis of cytokines, including interferons, T-cell immunosuppression, impaired intercellular cooperation, poor functional activity of natural killers and phagocytes. Despite the large range of means and methods of prophylaxis of infectious and inflammatory diseases of viral and bacterial etiology, it is necessary to search for new approaches taking into account the peculiarities of immune status in young children. The article presents the possibilities of controlling the system of congenital and adaptive immunity with medications, in particular, by using the bacterial lysate Broncho-munal®. The immunoregulatory role of bacterial lysates is presented in detail. The pathogenetic substantiation of the use of bacterial lysate Broncho-munal® for the prevention of acute respiratory infections in children, including children with recurrent respiratory infections is given.

Publisher

Remedium, Ltd.

Subject

General Medicine

Reference43 articles.

1. Zaplatnikov A.L., Girina A.L. More on frequently ill children problematics. Pediatriya = Pediatria. 2015;94(4):215–221. (In Russ.) Available at: https://pediatriajournal.ru/files/upload/mags/347/2015_4_4398.pdf.

2. Zaplatnikov A.L., Ivanov V.A., Sharapova N.V. RMZH = RMJ. 2007;21(302):389–408. (In Russ.) Available at: https://www.rmj.ru/articles/pediatriya/Chasto_boleyuschie_deti_prichiny_nedostatochnoy_effektivnosti_ozdorovleniya_i_rezervy_immunoprofilaktiki/.

3. Kravchenko I.A. Morbidity of preschool age children according to a sampling study. Detskaya bol’nitsa = Children’s Hospital. 2013;(2):6–9. (In Russ.) Available at: https://elibrary.ru/item.asp?id=21566537.

4. Samsygina G.A. Differential diagnostics of causes of frequent acute respiratory infections in children. Pediatriya = Pediatria. 2019;98(1):193-200. (In Russ.) Available at: http://pediatriajournal.ru/archive?show=368§ion=5457.

5. Bogomil’skiy M.R., Chistyakova V.R. Pediatric otorhinolaryngology. Moscow: GEOTAR-Media, 2002. 432 c. Available at: http://www.booksshare.net/books/med/bogomolskiymr/2002/files/detskayaotorinolaringooliya2002.pdf.