Conjunctival sac microbiome status and the use of picloxidine dihydrochloride in children with infectious conjunctivitis-Reference-Cited by-同舟云学术

Conjunctival sac microbiome status and the use of picloxidine dihydrochloride in children with infectious conjunctivitis

Published:2024-08-09 Issue:11 Volume: Page:221-227
ISSN:2658-5790
Container-title:Meditsinskiy sovet = Medical Council
language:
Short-container-title:Medicinskij sovet

Author:

Sakhovskaya N. A.¹^ORCID,Frolov M. A.¹^ORCID,Simonova A. V.²^ORCID

Affiliation:

1. Peoples’ Friendship University of Russia named after Patrice Lumumba

2. Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

Abstract

The surface of the eyeball presents a unique microbiocynosis, which is composed of various bacteria including viruses. Proceeding in the body itself. Infectious conjunctivitis in children is one of the most frequent and widespread processes, which determines the relevance of this problem. Inflammatory diseases can be both independent diseases and a reflection of negative processes of the eye.Aim. To evaluate the efficacy of picloxidine dihydrochloride in the composition 0.05% eye drops in the treatment of infectious conjunctivitis in children according to the results of conjunctival cavity microbiosis study by chromatography-mass spectrometry.Materials and methods. The study included 61 patients (104 eyes) with infectious conjunctivitis aged from 1 to 9 years (5.02 ± 0.25). The state of conjunctival cavity microbiocenosis was studied in all patients before treatment by chromato-mass spectrometry. All patients were prescribed instillations of picloxidine dihydrochloride as a part of eye drops 0.05% into conjunctival cavity with the frequency of 4 times a day.Results. A more severe course of conjunctivitis was recorded in children with less Bifidobacterium spp.Discussion. Dysbiosis of conjunctival sac microbiome reflects the reserve potential of the immunity of the bulbar conjunctiva. Due to emergence of 4 types of pathogenic microflora, cytomegalovirus (20% of patients) and a decrease in all types of normal flora, a significant increase in opportunistic microorganisms (12 types), 2 to 59.5-fold increase on average is recorded, and every 3rd patient is diagnosed with an increased titer of total endotoxin, which indicates the decreased reserve potential of the immunity of the bulbar conjunctiva.Conclusion. Antiseptic with picloxidine dihydrochloride 0.05% in the eye drops Piktorid-SOLOpharm is a broad spectrum drug in the treatment of infectious conjunctivitis in children without significant side effects.

Publisher

Remedium, Ltd.

Reference16 articles.

1. Kochergin SА, Tchernakova GM, Klescheva EA, Shapoval IM, Mezentseva MV. Immunity of eye-bulbe and conjunctive microflora. Russian Journal of Infection and Immunity. 2012;2(3):635–644. (In Russ.) https://doi.org/10.15789/2220-7619-2012-3-635-644.

2. Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P et al. An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells. Immunity. 2017;47(1):148–158. https://doi.org/10.1016/j.immuni.2017.06.014.

3. Doan T, Akileswaran L, Andersen D, Johnson B, Ko N, Shrestha A et al. Paucibacterial Microbiome and Resident DNA Virome of the Healthy Conjunctiva. Invest Ophthalmol Vis Sci. 2016;57(13):5116–5126. https://doi.org/10.1167/iovs.16-19803.

4. Polyakova АS, Tatochenko VK. Once again about the term “viral-bacterial infection”. Meditsinskiy sovet. 2015;(14):30–35. (In Russ.) https://doi.org/10.21518/2079-701X-2015-14-30-35.

5. Harbarth S, Samore MH. Antimicrobial resistance determinants and future control. Emerg Infect Dis. 2005;11(6):798–801. https://doi.org/10.3201/eid1106.050167.