Affiliation:
1. Pirogov Russian National Research Medical University
2. Pirogov Russian National Research Medical University;
First Phlebological Center
Abstract
Venous trophic ulcers are one of the most common in the population, and costly in terms of treatment costs for complications of chronic venous insufficiency. The prevalence of venous trophic ulcers ranges from 0.18 to 1%. Over the age of 65 it increases to 4%. The cause of the formation of venous trophic ulcers is chronic diseases of the veins of the lower extremities. Chronic disease of the veins is a term that includes a wide range of morphological and functional disorders affecting the venous system. At the same time, even after conservative treatment, the level of recurrence of venous trophic ulcers remains extremely high, which leads to an increase in the duration of treatment for patients in the hospital, in some cases causing permanent disability in patients of working age. The literature has accumulated a huge volume of both fundamental and clinical research on the etiology, pathogenesis, diagnosis and treatment of venous ulcers. However, despite the numerous studies, the number of patients with this disease continues to steadily increase, and a number of important aspects of the pathogenesis have not yet been studied. In addition, these works do not allow us to formulate a unified concept of the pathogenesis of venous ulcers, which in turn affects the effectiveness of treatment of venous trophic ulcers. Our study highlights modern aspects of the pathogenesis of venous trophic ulcers, which may be of key importance in the treatment of this pathology. Promising directions of scientific research in this area are determined. This requires a more in-depth study of aspects of intercellular interactions, and also opens up the prospect of searching for new methods of influencing the pathogenesis of venous trophic ulcers, taking into account the presence of microflora resistant to standard antibacterial agents.
Subject
Urology,Surgery,Gastroenterology,Cardiology and Cardiovascular Medicine,Anesthesiology and Pain Medicine
Reference63 articles.
1. Weller CD, Richards C, Turnour L, Patey AM, Russell G, Team V. Barriers and enablers to the use of venous leg ulcer clinical practice guidelines in Australian primary care: A qualitative study using the theoretical domains framework. Int J Nurs Stud. 2020;103:103503. https://doi.org/10.1016/j.ijnurstu.2019.103503.
2. Nicolaides A, Kakkos S, Eklof B, Perrin M, Nelzen O, Neglen P et al. Management of chronic venous disorders of the lower limbs – guidelines according to scientific evidence. Int Angiol. 2014;33(2):87–208. Available at: https://pubmed.ncbi.nlm.nih.gov/24780922/.
3. Darwin E, Liu G, Kirsner RS, Lev-Tov H. Examining risk factors and preventive treatments for first venous leg ulceration: A cohort study. J Am Acad Dermatol. 2021;84(1):76–85. https://doi.org/10.1016/j.jaad.2019.12.046.
4. Serra R, Ielapi N, Barbetta A, de Franciscis S. Skin tears and risk factors assessment: a systematic review on evidence-based medicine. Int Wound J. 2018;15(1):38–42. https://doi.org/10.1111/iwj.12815.
5. Vasudevan B. Venous leg ulcers: Pathophysiology and Classification. Indian Dermatol Online J. 2014;5(3):366–370. https://doi.org/10.4103/2229-5178.137819.
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