Affiliation:
1. Saint Petersburg Research Institute of Ear, Throat, Nose and Speech
Abstract
AbstractIntroduction. The presence of opportunistic pathogens within the nasal cavity is one of the important factors in the pathogenesis of acute rhinosinusitis and exacerbation of chronic rhinosinusitis. On top of that, the frequently prescribed ill-founded and uncontrolled use of antibiotics leads to the development of immunoresistance, which contributes to the lack of effectiveness of conservative treatments. This article discusses the therapeutic option for patients with acute rhinosinusitis and exacerbation of chronic rhinosinusitis in the form of a silver proteinate drug in the complex treatment.Aim. To evaluate the effectiveness of the silver proteinate drug in the complex treatment of acute rhinosinusitis and exacerbation of chronic rhinosinusitis.Materials and methods. A total of 60 adult patients of both sexes aged 20 to 50 years were included in the study. The first study group (a treatment group) included 30 patients (15 with acute rhinosinusitis and 15 with exacerbation of chronic rhinosinusitis). The second group (a comparison group) also included 30 patients (15 with acute rhinosinusitis and 15 with exacerbation of chronic rhinosinusitis). The treatment group received the silver proteinate drug + decongestants + irrigation therapy + topical corticosteroid therapy as part of the complex treatment. The comparison group received standard therapy: irrigation therapy (solutions to rinse nasal cavities) + decongestants + topical corticosteroid drugs.Results. Comparative analysis of re-assessment scores for the patients’ status against the timing of use of the silver proteinate drug (Sialor®, tablets for solution for topical use, 200 mg) in the complex treatment showed pronounced improvement in the form of rapid relief of symptoms of the disease and recovery in patients with acute rhinosinusitis and exacerbation of chronic rhinosinusitis in both study groups.Conclusion. This brings us to the conclusion about the effectiveness and safety of the silver proteinate drug Sialor® in the complex treatment of patients with acute rhinosinusitis and exacerbation of chronic rhinosinusitis, which allows us to recommend it for widespread use in otorhinolaryngological practice.
Reference28 articles.
1. Kryukov AI, Tsarapkin GYu, Tovmasyan AS, Gorovaya EV, Vershinina EA. Administration of topical antimicrobial agents in the complex treatment of upper respiratory tract pathology. RMJ. 2020;(5):32–42. (In Russ.) Available at: https://www.rmj.ru/articles/otorinolaringologiya/Primenenie_mestnyh_antimikrobnyh_sredstv_v_kompleksnom_lechenii_patologii_verhnih_dyhatelynyh_putey.
2. Budkovaya MA, Artemyeva ES. The specific features of nasal breathing disorders in patients with nasal obstruction. Rossiiskaya Otorinolaringo logiya. 2019;18(1):16–23. (In Russ.) https://doi.org/10.18692/1810-4800-2019-1-16-23.
3. Shilenkova VV, Fedoseeva OV. Nasal cycle and rhinosinusitis: a new look at the problem. Rossiiskaya Otorinolaringologiya. 2019;18(2):70–76. (In Russ.) https://doi.org/10.18692/1810-4800-2019-2-70-76.
4. Zolotareva MA, Nazaruk EI. Orbital and intracranial complications of inflammatory diseases of paranasal sinuses in adults based on case studies of Department of Otorhinolaryngology of N. A. Semashko Republican Clinical Hospital for the period 2014 to 2018. Rossiiskaya Otorinolaringologiya. 2020;19(1):37–45. (In Russ.) https://doi.org/10.18692/1810-4800-2020-1-37-45.
5. Krivopalov AA, Moroz NV, Artyushkin SA, Shamkina PA, Zakharova GP. Assessment of prevalence of chronic rhinosinusitis. Rossiiskaya Otorinolaringologiya. 2022;21(5):91–98. (In Russ.) https://doi.org/10.18692/1810-4800-2022-5-91-98.
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