Diffusion Tensor Imaging of the Spinal Canal in Quantitative Assessment of Patients with Lumbar Spinal Canal Stenosis

Author:

Norimoto Masaki,Eguchi Yawara,Kanamoto Hirohito,Oikawa Yasuhiro,Matsumoto Koji,Masuda Yoshitada,Furuya Takeo,Orita Sumihisa,Inage Kazuhide,Maki Satoshi,Shiga Yasuhiro,Kinoshita Hideyuki,Abe Koki,Inoue Masahiro,Umimura Tomotaka,Sato Takashi,Sato Masashi,Suzuki Masahiro,Enomoto Keigo,Ohtori Seiji

Abstract

<sec><title>Study Design</title><p>Retrospective observational study.</p></sec><sec><title>Purpose</title><p>Lumbar spinal stenosis (LSS) has traditionally been evaluated morphologically, there is a paucity of literature on quantitative assessment of LSS. The purpose of this study was to investigate whether intraspinal diffusion tensor imaging (DTI) parameters such as apparent diffusion coefficient (ADC) and fractional anisotropy (FA) are useful for assessing LSS.</p></sec><sec><title>Overview of Literature</title><p>Quantitative assessment of LSS is challenging.</p></sec><sec><title>Methods</title><p>Study participants comprised five healthy volunteers (mean age, 27.2 years) and 27 patients with LSS (mean age, 58.4 years) who were individually assessed using 3.0 Tesla magnetic resonance imaging. Intraspinal ADC and FA values of 10 intervertebral discs from healthy volunteers and 52 intervertebral discs from LSS patients were measured. Also, intraspinal canal area, Schizas classification (A: normal, B: mild stenosis, C: severe stenosis) and correlations with symptoms were investigated. Clinical symptoms were checked for the presence of low back pain (LBP), intermittent claudication (IMC), and bladder and bowel dysfunction (BBD).</p></sec><sec><title>Results</title><p>Compared to healthy individuals, LSS patients had significantly lower ADC (<italic>p</italic><0.05) and significantly higher FA values (<italic>p</italic><0.01). In Schizas classification, stenosis worsened from A to C. ADC values decreased significantly while FA values increased significantly in that order (<italic>p</italic><0.05). A positive correlation was found between intraspinal canal area and ADC values (<italic>r</italic>=0.63, <italic>p</italic><0.01) and a negative correlation between intraspinal canal area and FA values (<italic>p</italic>=−0.61, <italic>p</italic><0.01). No correlations were noted between LBP and ADC or FA values. On the other hand, ADC values were significantly lower (<italic>p</italic><0.05) and FA values were significantly higher (<italic>p</italic><0.05) in patients with IMC or BBD.</p></sec><sec><title>Conclusions</title><p>Intraspinal DTI parameters such as ADC and FA values were associated with the Schizas classification, intraspinal canal area, and clinical symptoms, suggesting that ADC and FA may be useful for quantitative assessment of LSS.</p></sec>

Publisher

Asian Spine Journal (ASJ)

Subject

Orthopedics and Sports Medicine,Surgery

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3