Comparison of Intraoperative Low-Dose Ketodex and Fentanyl Infusion for Postoperative Analgesia In Spine Surgery: A Prospective Randomized Double-Blind Study

Author:

Thappa PriyaORCID,Singh NidhiORCID,Luthra AnkurORCID,Deshpande PruthvirajORCID,Chauhan RajeevORCID,Meena Shyam C.ORCID,Kumar VishalORCID,Singla NavneetORCID

Abstract

Study Design: Prospective randomized double-blind study.Purpose: To assess the analgesic effects of the combination of a low-dose ketamine and dexmedetomidine (ketodex) infusion and compare it with that of fentanyl for postoperative analgesia after spine surgeries.Overview of Literature: Adequate pain management following spine surgeries is crucial. Approximately 57% of patients experience inadequate pain control in the first 24 hours following elective spine surgery, which is attributable to the extensive soft tissue and muscle damage.Methods: The study included 60 patients graded American Society of Anesthesiologists I and II and scheduled for thoracolumbar spine surgery involving >3 vertebral levels. The patients were divided into two groups: group KD (ketodex) and group F (fentanyl). The primary objective was to compare the postoperative analgesic requirements among the groups. The secondary objectives included a comparison of the intraoperative anesthetic requirements, postoperative pain scores, hemodynamic parameters, side effects of the study drugs, and the duration of post-anesthesia care unit stay of both the groups.Results: Ketodex use prolonged the mean time to first rescue analgesia (22.00±2.30 hours vs. 11.69±3.02 hours, <i>p</i> <0.001) and reduced the requirement of rescue analgesics in the first 24 hours postoperatively compared to fentanyl use (70.00±8.16 μg vs. 113.31±36.65 μg, <i>p</i> =0.03). The intraoperative requirement of desflurane was comparable between the groups (<i>p</i> >0.05). The postoperative pain scores were significantly lower in the group KD than in group F at most timepoints (<i>p</i> <0.05). Patients in group KD had a shorter post-anesthesia care unit stay than group F did (<i>p</i> <0.001).Conclusions: Low-dose ketodex could be a safe substitute for fentanyl infusion when employed as an anesthetic adjuvant for patients undergoing thoracolumbar spine surgeries involving >3 vertebral levels to achieve prolonged analgesia without any opioidrelated side effects.

Publisher

Asian Spine Journal (ASJ)

Subject

Orthopedics and Sports Medicine,Surgery

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Opioid alternatives in spine surgeries;Current Opinion in Anaesthesiology;2024-08-06

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