Clinical-epidemiological and pathogenetic features of viral hepatitis C in the hemodialysis departments

Author:

Akalaev R. N.1ORCID,Aripkhodzhaeva G. Z.2ORCID,Rashidova S. A.2ORCID,Abdullaev A. N.3ORCID,Khashimov K. A.4ORCID

Affiliation:

1. Tashkent Institute of Postgraduate Medical Education; Republican Research Centre of Emergency Medicine

2. Tashkent Pediatric Medical Institute

3. Tashkent Institute of Postgraduate Medical Education; Scientific Research Institute of Epidemiology, Microbiology and Infectious Diseases

4. Tashkent Institute of Postgraduate Medical Education

Abstract

Background. Today, the programmed hemodialysis belongs to the clinical medicine area where patients are at a constant risk of viral hepatitis infection. This is associated with surgical interventions on the vessels, fairly frequent transfusions of blood components, and regular hemodialysis procedures. But in recent years, the ratio of reported cases of viral hepatitis B and C in patients on programmed hemodialysis has changed significantly. With an abrupt increase in the incidence of viral hepatitis C, there is a decrease in the number of registered viral hepatitis B cases.The aim. To study the clinical, epidemiological and pathogenetic features of viral hepatitis C in hemodialysis units.Material and methods. A multicenter study was conducted that enrolled the patients from the Programmed Hemodialysis Units in Tashkent and the regional departments of the Republic of Uzbekistan. The study involved 395 patients on programmed hemodialysis for 7.5 ± 0.7 years. The age of patients was 43.5 ± 0.91 years. The diagnosis of chronic viral hepatitis C was made on the basis of medical history, clinical and laboratory data, and detection of anti-HCV IgG and RNA-HCV in blood.Results. When analyzing the clinical examination and laboratory test results of 395 patients, the parenteral viral infection markers were detected in 181 patients (45.8%). The analysis of the overall incidence of viral hepatitis showed that chronic viral hepatitis C had the highest rates and was found in 125 patients (31.6%). The analysis of the chronic viral hepatitis C course in the presence of the end-stage chronic renal disease showed that in 11 (34%) of 32 patients of the Main group the disease proceeded as a fulminant form of chronic renal-hepatic failure with the development of adverse outcomes. Twenty seven patients (84%) in this group developed progressive anemia. In 16 patients (50%), persistent polyserositis developed in the form of hydrothorax, ascites, and pericarditis, which reflected the aggravating effect of chronic viral hepatitis C on the course of chronic renal disease.Conclusions. In Hemodialysis Units, both in the city of Tashkent, and in the regional departments of the Republic of Uzbekistan, the incidence of chronic viral hepatitis C prevails, having the form of a pathological process with a minimally low activity. Chronic viral hepatitis C has an aggravating effect on the course of the underlying disease with the development of adverse outcomes.

Publisher

IPO Association of Transplantologists

Subject

Transplantation,Immunology,Immunology and Allergy,Surgery

Reference10 articles.

1. Kuznetsov NI, Romanov ES, Startseva GYu. Modern principles of anti-viral therapy of hepatitis C. Russian Family Doctor. 2018;22(3):23–27. (In Russ.). https://doi.org/10.17816/RFD2018323-27

2. Arisheva OS, Moiseev SV, Kotenko ON. Daclatasvir and asunaprevir combination in hemodialysis patients with chronic hepatitis C. Clin Pharmacol Ther. 2016,25(3):5–10. (In Russ.).

3. Akimkin VG, Semenenko TA, Nikitina GYu, Godkov MA, Skvortsov SV. Epidemiology of hepatitis B and C in treatment and prophylactic institutions. Moscow: Bionics Publ.; 2013. (In Russ.).

4. Milovanova SYu, Milovanov YuS, Kozlovskaya LV, Komyagin YuV. Profilaktika i lecheniye virusnykh gepatitov B i C u bolnykh na programmnom gemodialize. Gepatologicheskiy forum. 2009;(4):19–26. (In Russ.).

5. Yarosh LV, Semenenko TA, Nikitina GYu, Shutov EV, Elgort DA, Feldsherova AA, et al. Prevalence of the hepatitis B and C viruses markers in the hemodialysis departments. Nephrology and dialysis. 2013;15(4):293–298. (In Russ.).

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3