Association of TPO Gene (rs 2048722) Polymorphisms and Serum Level of Thyroid Hormones with Papillary Thyroid Cancer

Abstract

Background: Papillary thyroid carcinoma (PTC) is the most prevalent form of thyroid cancer, making up about 80% of cases. It is influenced by both genetic and environmental factors, making it the most prevalent form of thyroid cancer. Objective: Determine the connection between PTC and polymorphisms in the thyroid peroxidase gene (TPO, rs2048722) as a risk factor, as well as the changes in thyroid hormone serum levels. Methods: The study involved 52 PTC patients and 48 healthy controls. We looked into the link between a type of TPO polymorphism and the risk of getting PTC by finding and genotyping TPO (rs2048722) C/T in healthy people and people who had PTC using T-ARMS-PCR and checking thyroid hormone levels in the Al-Diwaniyah Governorate. Results: The polymorphism TPO (rs2048722) increased the PTC risk. According to multiple genetic models, homozygous TT genotypes increased the risk of PTC in the test by 4.03 times relative to other genotypes, and a heterozygous C/T genotype increased the risk by 2.09 times. Patients with PTC have elevated TSH. Patients over 50 exhibited greater mean values than the control group. In addition, T3 and T4 blood levels dropped significantly and increased overall. Compared to other groups, patients aged 50 and older had lower mean T3 levels. Conclusions: In the Al-Diwaniyah Governorate, there was strong evidence that the TPO rs2048722 polymorphism was linked to a higher risk of PTC. This risk was affected by age, gender, and serum thyroid hormone levels.