The Promising Role of Flavonoids in Chronic Obstructive Pulmonary Disease

Abstract

Background: Flavonoid-rich foods are beneficially associated with enhancing pulmonary function; however, the protective effects of flavonoids may have an impact on COPD through anti-inflammatory mechanisms. Chronic obstructive pulmonary disease (COPD) is a prevalent lung disease with a high death rate and multiple health problems. Recently, up to 7000 flavonoids have been identified as having anticancer, antioxidant, and anti-inflammatory properties. Various mechanisms of action of flavonoids have been implicated. Aim: This review aims to identify and appraise various flavonoids used in managing COPD and reveal their mechanisms. Methods: We searched the Web of Sciences, Google Scholar, PubMed, Scopus, and EMBASE databases from December 1975 to February 2022 by using the relevant keywords for this narrative review. Results: Many flavonoids were found to be effective in the management of COPD, such as liquiditin apioside, quercetin, baicalin, naringin, hesperidin, silymarin, and casticin. The proposed mechanisms for these flavonoids could either be attributed to antioxidant or anti-inflammatory activity. Conclusion: Flavonoids could be a promising alternative to be developed and tested for the treatment of COPD in clinical settings.