Estimation of Tenascin-C Levels in Iraqi Patients with Diabetic Nephropathy

Abstract

Background: Diabetic nephropathy (DN) is a highly malignant chronic microvascular complication of diabetes that is the principal cause of end-stage renal disease (ESRD). Objective: The purpose of this study is to ascertain the correlation between diabetic nephropathy and Tenascin-C (TNC), in addition to quantifying TNC levels at different phases of this pathogenesis. Methods: Thirty healthy subjects and ninety T2DM patients participated in this cross-sectional study. Patients were divided into three groups according to the albumin-creatinine ratio (ACR): normal albuminuria, microalbuminuria, and macroalbuminuria. By employing an ELISA reagent, the serum TNC concentration was ascertained. Results: Significant disparities were observed in the concentrations of TNC and FBG, TC, TGs, HDL, LDL, and VLDL between individuals with diabetic nephropathy and those who were in good health. There were also substantial differences between the levels of TNC and kidney function in patients with various disease stages. Furthermore, a noteworthy positive correlation was identified between TNC and blood concentrations of ACR, urea, and creatinine. Conclusions: Based on the available evidence, it can be deduced that TNC may serve as the most precise predictor of diabetic nephropathy and may be associated with its progression.