A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair-Reference-Cited by-同舟云学术

A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair

Published:2016-05-27 Issue:1 Volume:7 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Florio Monica,Gunasekaran Kannan,Stolina Marina,Li Xiaodong,Liu Ling,Tipton Barbara,Salimi-Moosavi Hossein,Asuncion Franklin J.,Li Chaoyang,Sun Banghua,Tan Hong Lin,Zhang Li,Han Chun-Ya,Case Ryan,Duguay Amy N.,Grisanti Mario,Stevens Jennitte,Pretorius James K.,Pacheco Efrain,Jones Heidi,Chen Qing,Soriano Brian D.,Wen Jie,Heron Brenda,Jacobsen Frederick W.,Brisan Emil,Richards William G.,Ke Hua Zhu,Ominsky Michael S.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms11505.pdf

Reference43 articles.

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2. Li, X. et al. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J. Biol. Chem. 280, 19883–19887 (2005).

3. van Bezooijen, R. L. et al. Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J. Exp. Med. 199, 805–814 (2004).

4. Brunkow, M. E. et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am. J. Hum. Genet. 68, 577–589 (2001).

5. Balemans, W. et al. Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. J. Med. Genet. 39, 91–97 (2002).

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