Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes-Reference-Cited by-同舟云学术

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

Published:2016-03-31 Issue:1 Volume:7 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Bacos Karl,Gillberg Linn,Volkov Petr,Olsson Anders H,Hansen Torben,Pedersen Oluf,Gjesing Anette Prior,Eiberg Hans,Tuomi Tiinamaija,Almgren Peter,Groop Leif,Eliasson Lena,Vaag Allan,Dayeh Tasnim,Ling Charlotte

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms11089.pdf

Reference70 articles.

1. Chang, A. M. & Halter, J. B. Aging and insulin secretion. Am. J. Physiol. Endocrinol. Metab. 284, E7–12 (2003).

2. Ling, C. & Groop, L. Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 58, 2718–2725 (2009).

3. Dayeh, T. et al. Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet. 10, e1004160 (2014).

4. Volkmar, M. et al. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J. 31, 1405–1426 (2012).

5. Yang, B. T. et al. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. Diabetologia 54, 360–367 (2011).

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